Effects of various NSAIDs on prostaglandin synthesis and cellular configuration of human periodontal ligament cells

The present study was designed to evaluate effects of the commonly used NSAIDs(acetaminophen, aspirin, and ibuprofen) on human periodontal ligament cells. Human periodontal ligament cells were grown from a cell line provided by Kyungpook National University. Effects of NSAIDs on the proliferation of human periodontal ligament cells were assessed using MTT assays. And then PGE2 concentrations were determined by ELISA and the changes of cellular configuration were found by electron micrograph. The results were as follows; 1. The MTT assay demonstrated that the commonly used NSAIDs(acetaminophen, aspirin, and ibuprofen) had not significant cytotoxic effect on human periodontal ligament cells. 2. NSAIDs inhibited the PGE2 synthesis of human periodontal ligament cells compared with the control group. These inhibitory effects had no significant differences with NSAID type and concentration. 3. Electron micrographs of human periodontal ligament cells treated with NSAIDs showed more narrow and irregular shape.

A study on the anterior tooth size discrepancies among orthodontic patients with varying malocclusions / 대한치과교정학회지

Bolton analysis is widely used to predict tooth size discrepancy, but its accuracy has been challenged. The purpose of this study was to describe true anterior tooth size discrepancies among orthodontic patients and to evaluate the factors that affect true anterior tooth size discrepancies. The subjects consisted of 80 patients with varying malocclusions (Class I, Class II, Class III, and Class III surgery) who were treated orthodontically. Pre-treatment models, set-up models from post-treatment models, and lateral cephalometric radiographs were analyzed. The results were as follows. The means, the standard deviations, and ranges of anterior Bolton ratio in the present study were somewhat higher than those of Bolton's samples and Korean normal samples. The number of patients showing maxillary deficiency was larger than that of patients showing maxillary excess in view of true anterior discrepancies. There was a significant difference between anterior Bolton discrepancy from pre-treatment models and true anterior discrepancy from set-up models (p 0.05). And there was also no significant difference between the male and female groups (p > 0.05). Overbite and the incisal edge thickness of maxillary anterior teeth have little relationship with true anterior discrepancies. Multiple regression analysis showed that true anterior discrepancy was mainly determined by anterior Bolton ratio, upper incisor to occlusal plane angle after treatment, interincisal angle after treatment, and upper right lateral incisor width.

Surgical Outcome of Spontaneous Intracerebral Hemorrhage in Less than Stuporous Mental Status

OBJECTIVE: Spontaneous supratentorial intracerebral hemorrhage can be considered as one of the most common forms of cerebravascular disease. Effective reduction of intracranial volume buffering capacity in elevated intracranial pressure is most important factor related to a poor prognosis in cases with huge hematoma and compromised mental status. The role of surgery in the management of such cases are still controversial. METHODS: Thirty patients with altered mental status less than stuporous and spontaneous supratentorial hematoma were underwent craniotomy or decompressive craniectomy and duroplasty. The hematoma volume were ranging from 31 to 120ml. In 14 patients, in whom a progression in secondary brain swelling was expected to occur after hematoma evacuation, a decompressive craniectomy with dural enlargement was performed. The overall clinical result was expressed as 30 day mortality, Glasgow outcome scale(GOS) and modified Rankin scale 1 year after surgery. The favorable outcome(GOS> or =4) were analyzed with variables [age, initial Glasgow coma scale(GCS), hematoma volume, location of hematoma, extent of midline shift, intraventricular hemorrhage, and time interval from ictus to surgery]. RESULTS: The overall clinical results showed 10% of 0-day mortality, 56.6% of favorable outcome and 53.3% of independency(< or =2 of modified Rankin scale). A significant statistical correlation was found between outcome and initial GCS and location of hematoma(p<0.05). The decompressive craniectomy and duroplasty proved some useful in increasing postoperative GCS of compromised patients. CONCLUSION: Surgical treatment of patients with spontaneous supratentorial intracerebral hemorrhage with altered mentality less than stuporous can have a positive role, in selected cases.

Clinical Analysis of Determining the Primary Rupture Site in Multiple Intracranial Aneurysms: Preliminary Report

OBJECTIVE: Misjudgement of rupture site may result in disastrous postoperative rebleeding from the unclipped but truly ruptured aneurysm. We assess the concordance rate between radiologic findings and operative ones, and then we document the problems in false localization of rupture site in multiple intracranial aneurysms. METHODS: From January 2001 to December 2002, We retrospectively analyzed 14 patients with a total of 32 multiple aneurysms to assess the primary rupture site. The rupture site was determined on the basis of computed tomographic and angiographic findings by neurosurgeons and one neuroradiologist. The operative findings such as healed thrombotic cap, localized clot, and easy collapse before and after clipping of ruptured aneurysms were compared with the predicted radiologic findings. On the other hand, we analyzed the causes in the cases of false localization. RESULTS: The location of ruptured aneurysm was verified at the time of surgery in 10 patients. The concordance rate of localized clot(100%) was higher than laterality of subarachnoid hemorrhage(66.7%) on CT scan, and those of focal vasospasm and nipple formation(100%) were also higher than size(72.7%) or irregularity(83.3%) of aneurysms on angiographic findings. Two of four misjudged patients were expired due to rebleeding from unclipped aneurysms. CONCLUSION: Although most reliable radiologic findings are useful in determination of rupture site, we should also consider less reliable radiologic findings and careful surgical inspection of the target aneurysm. And then early second operation should be performed as soon as possible in cases of misjudgment on initial diagnosis.

Minor Salivary Gland Carcinoma Extending to Intracranial, Retroorbital and Sinonasal Cavity: Case Report

We report a case of huge minor salivary gland carcinoma extending to intracranial, retroorbital and sinonasal cavities. The patient was a 51-year-old man who had progressive nasal obstruction, decreased visual acuity and headache. Brain computed tomography and magnetic resonance image revealed a huge heterogeneous enhancing mass with extensive bony destruction originating from right maxillary sinus and both nasal cavities to the frontal base structures. The tumor mass was approached by a craniofacial route and subtotal removal was done because of its marked invasion of cavernous sinus, parasellar structures and hypothalamus. The histological diagnosis was minor salivary gland adenocarcinoma.